Association between RS266729 polymorphism of adiponectin ge

Association between RS266729 polymorphism of adiponectin gene with type 2 diabet in diabetic patients in jahrom city

Saeideh Erfanian¹, kavus solhju², maryam khallashi³

1. Master of science biochemistry,  Jahrom University of Medical Sciences, Jahrom, Iran

2. Department of microbiology, Jahrom University of Medical Sciences, Jahrom, Iran

3. Medical student, Jahrom University of Medical Sciences, Jahrom, Iran

• A signaling molecule that is secreted from white and brown adipose tissue.
• Composed of 247 amino acids.
• Accounts for 0.05 % of total serum protein.
• Concentration: 2~20 μg/mL in the blood
• The gene for adiponectin is located on chromosome 3q27.
• This region of the chromosome has also been linked to type 2 diabetes.
• A SNP located 276 base pairs downstream of the start site of the adiponectin gene was associated with increased insulin resistance and risk of developing type 2 diabetes.